The PM42 was specifically designed to work with Digitrax Direct Home wired layouts. Any system that is configured this way will work with the PM42 with no interoperability issues. For example, CVP uses interoperable booster connections.
The PM42 can be used with a DC system if it is hooked up in the negative ground return path, or even a Marklin AC digital (trinary) booster. It is possible for the PM42 to be used with most DCC systems. Digitrax has no control or knowledge of each specific non-Digitrax system and how it may interact with the PM42.